Laboratory for
Neuroimmunology
in Health and Diseases

Research & Approaches

Neuronal and immune interactions play a critical role in maintaining physiological homeostasis and responding to pathological challenges. Understanding these interactions is essential for unraveling the mechanisms underlying both health and disease. Our research group employs a multidisciplinary approach, combining cutting-edge techniques such as two-photon in vivo brain imaging, slice electrophysiology, and patch-seq, to investigate the dynamic interplay between neuronal activity and immune responses in the brain. These tools allow us to visualize, record, and analyze cellular and molecular processes with high spatial and temporal resolution, providing insights into how these systems adapt under varying conditions.

A particular focus of our work is the impact of intermittent fasting on brain health and disease. Intermittent fasting, a dietary intervention characterized by cycles of fasting and feeding, has garnered significant attention for its potential to promote metabolic health, enhance cognitive function, and mitigate neuroinflammation. However, the precise mechanisms by which intermittent fasting influences neuronal and immune activities remain poorly understood. By studying these processes in both physiological and pathological contexts, we aim to elucidate how intermittent fasting modulates brain function and resilience, offering potential therapeutic strategies for neurodegenerative diseases, neuroinflammation, and other brain-related disorders.

Through our integrative approach, we strive to bridge the gap between cellular-level insights and whole-brain function, advancing our understanding of how lifestyle interventions like intermittent fasting can shape brain health and disease outcomes.