Neuroscience, Diseases & Related Sciences Symposium

神经科学及其交叉学科前沿系列研讨会

Neurological Diseases, Microglia and Interventions

Novermber 12, 2024 9:00 | Guangzhou Bio-Island

Center for Medical Research on Innovation & Translation, Guangzhou First People's Hospital, an Affiliated Hospital of South China University of Technology and Guangzhou Medical University

广州市第一人民医院
广州医科大学附属市一人民医院/华南理工大学附属第二医院

主办方：
广州市第一人民医院医学研究与创新转化中心
广州市第一人民医院神经免疫与健康实验室(LNHD.org)
广州市第一人民医院徕卡显微系统共建实验室

协办方：
HONGKONG PLEXON
Leica Microsystem

Syposium overview：The Neuroscience, Diseases & Related Sciences Symposium of Guangzhou First People's Hospital aims to explore global frontiers and research methodologies in both clinical and basic neuroscience as well as related fields. The symposium seeks to promote the development of neuroscience and its interdisciplinary branches.

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○ 9:00-9:10 会议介绍
广州市第一人民医院

○ 9:10-9:55 Microglial P2Y6 calcium signaling regulates neuroimmune response in epilepsy
WU, Long-Jun | 伍龙军 The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School at UTHealth, Houston, USA

BIO: Long-Jun Wu, PhD, is the C. Harold and Lorine G. Wallace Distinguished University Chair at the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM). He also serves as the Professor and Founding Director at IMM – Center for Neuroimmunology and Glial Biology. In this role, Dr. Wu is building an interdisciplinary research center dedicated to understanding brain immune system for future neuroimmune therapy for brain diseases. He was Professor of Neurology and Neuroscience at Mayo Clinic prior to joining UTHealth Houston in 2024. Dr. Wu is interested in studying the role of microglia, the highly dynamic immune cells in the central nervous system, in clinically relevant pathologies such as epilepsy, neuropathic pain, neurodegeneration and autoimmune neurology. His research laboratory focuses on neuroimmune innteraction in normal and diseased brain tissue. Particularly, he and his team study the molecular mechanism underlying microglial sensing and regulation of neuronal activities. The use of advanced genetic tools along with a combination of two-photon imaging, electrophysiology, electroencephalography, molecular biology techniques and awake-behavioral studies in rodent models help Dr. Wu and his team identify microglia-specific targets to treat brain diseases, such as epilepsy, chronic pain, neurodegeneration etc.
伍龙军，现任布朗基金会分子医学研究所（IMM）预防人类疾病部的C. Harold和Lorine G. Wallace杰出大学讲席教授。同时，他担任IMM神经免疫与胶质生物学中心的教授及创始主任。在该岗位上，伍教授致力于创建一个跨学科研究中心，旨在深入了解大脑免疫系统，为未来的脑疾病神经免疫治疗奠定基础。2024年加入德州大学健康科学中心休斯顿分校（UTHealth Houston）之前，他曾在梅奥诊所担任神经病学和神经科学教授。伍教授的研究兴趣集中在小胶质细胞——中枢神经系统内高度动态的免疫细胞——在临床相关病理如癫痫、神经性疼痛、神经退行性疾病和自身免疫性神经病中的作用。他的实验室重点研究正常及病变脑组织中的神经免疫相互作用，尤其关注小胶质细胞感知和调节神经元活动的分子机制。他的团队利用先进的基因工具，结合双光子成像、电生理学、脑电图、分子生物学技术以及清醒状态下的行为研究，识别小胶质细胞特异性靶标，以便治疗如癫痫、慢性疼痛、神经退行性疾病等脑疾病。

○ 9:55-10:40 Turnover and replacement of microglia
PENG, Bo | 彭勃 复旦大学 脑科学转化研究院 Institute for Translational Brain Research, Fudan University

BIO: Dr. Bo Peng is a professor and assistant director at Institute for Translational Brain Research, Fudan University. He obtained his bachelor's degree in biotechnology in 2008 at Huazhong University of Science and Technology. He then studied neurophysiology at the Institute of Neuroscience at the Chinese Academy of Sciences from 2008 to 2011. After that, he investigated retinal degenerative disorders at The University of Hong Kong and obtained his Ph.D. degree in neuroscience in 2015. After that, Dr. Bo Peng joined Shenzhen Institutes of Advanced Technology at the Chinese Academy of Sciences as an associate professor and established his lab. In 2019, Dr. Bo Peng moved to Fudan University. Dr. Bo Peng's laboratory is mainly focusing on understanding how microglia turnover in physiological and pathological conditions. In addition, his lab is developing therapeutic approaches for treating CNS disorders. Dr. Bo Peng published a series of last-author papers, including Nature Neuroscience (2018), Nature Aging (2023), Neuron (2021), Cell Reports (2020), Nature Communications (2022), and eLife (2023).
彭勃，复旦大学教授，博士生导师。教育部长江学者特聘教授，科技部重大项目首席科学家（4800万），Elsevier（爱思唯尔）中国高被引学者，教育部科技领军人才团队负责人，上海市领军人才。担任脑科学转化研究院院长助理，教育部免疫炎症疾病原创药物医药基础研究创新中心副主任，中国细胞生物学会神经细胞分会副会长，中国神经科学学会胶质细胞分会副主任委员，上海市神经科学学会理事。主持国家自然科学基金优秀青年科学基金等项目。 彭勃教授主要关注中枢神经系统内小胶质细胞的更替、细胞重编程，对机体的麻醉状态调控，以及在多种神经退行性病变中以小胶质细胞替换/移植为思路开展干预和治疗的全新策略。此外，课题组关注小胶质细胞在中枢神经系统稳态维持中的相关机理。自课题组成立以来，主要成果以最后通讯作者发表在Nature Neuroscience, Nature Aging, Neuron, Cell Reports, Nature Communications和eLife等高水平期刊上。彭勃课题组研究工作被Nature Reviews Immunology评选为2018神经免疫学年度科学进展。

○ 10:40-11:25 Precise Anesthetic Strategies for Peri-operative Cognitive Dysfunction in Geriatric Patients
TIAN, Li | 田莉 同济大学附属上海市第四人民医院 上海市麻醉与脑功能调控重点实验室 Key Laboratory of Anesthesia and Brain Function Regulation, Shanghai Fourth People's Hospital, Tongji University

BIO: Dr. Li Tian currently presides as the Director of the Research Department at the Shanghai Fourth People's Hospital, an esteemed affiliate of Tongji University. She concurrently holds the position of Deputy Director at the Key Laboratory of Anesthesia and Brain Function Regulation in Shanghai. In the academic realm, she is lauded as a Distinguished Professor at the Tongji University, guiding doctoral students and serving as an Associate Chief Physician in the domain of Anesthesia and Perioperative Medicine. Inaugurating an academic portfolio, she serves as the Deputy Chair of the Youth Committee of the Anesthesiology Branch of the Shanghai Medical Association and as the Secretary-General of the Anesthesia and Brain Science Branch of the Shanghai Neuroscience Society. Her remarkable strides in her field has garnered numerous accolades including the National Excellent Young Scientist, Shanghai Talent Development Fund, Shanghai Rising Star of Youth Science and Technology, Ministry of Education's Young Backbone Teacher of Higher Education Institutions, and Outstanding Young Anesthesiologist by the Anesthesia Branch of the Chinese Medical Association, to name a few.She was awarded as the "Shuguang Scholar of the Shanghai Municipal Education Commission" for her outstanding contributions. Leading national-level projects funded by the Natural Science Foundation, her research contributions comprise ten provincial projects and 36 SCI papers published in reputable academic journals such as InfoMat, Adv Sci, BJA, and more. Additionally, her innovative endeavors have been substantiated by six domestic patent authorizations and she has contributed to the compilation and translation of five academic monographs.
田莉博士，同济大学附属上海市第四人民医院科研部部长，上海市麻醉与脑功能调控重点实验室副主任，同济大学青百A岗特聘教授，博士生导师。担任上海市医学会麻醉学分会青年委员会副主任委员、上海市神经科学学会理事、上海市医学伦理学会理事、上海市医院协会临床研究管理专业委员会委员等任职。获国家优青、教育部优秀青年团队培育建设项目负责人、上海市曙光学者、上海市人才发展基金、上海市青年科技启明星、教育部高校青年骨干教师等。作为负责人主持国家自然科学基金、科技部重点研发课题等省部级以上项目10余项，获华夏青年医学科技奖、虹口区嘉奖、虹口区巾帼人才等荣誉。研究成果以第一/通讯作者在包括 InfoMat,Adv Sci, BJA等学术期刊发表SCI论文30余篇。授权国内专利6项，主编主译各类学术专著6部。

○ 11:25-12:10 NMDAR抗体的致病性研究
WANG, Honghao | 汪鸿浩 广州市第一人民医院神经内科 Guangzhou First People's Hospital

BIO：汪鸿浩，广州市第一人民医院神经内科主任、主任医师、博士生导师， 广东省医学杰出青年人才，广州市医学重点人才，中国卒中学会免疫分会常委，中华医学会神经病学分会神经免疫学组委员，中国免疫学会神经免疫分会委员，中国医师协会神经免疫专业委员会委员，广州市医学会神经内科分会副主任委员，广东省神经病学会神经免疫学组副组长，广东省精准医学会 中枢神经免疫和感染分会主任委员，主持国家自然基金3项，省部级基金7项， 排名第一或末尾通讯论文47篇，影响因子超过240分，被引1500余次。

○ 14:30-15:00 Glial regulation of neuropathic pain and itching
PENG, Jiyun | 彭吉云 杭州师范大学 脑科学研究所 Institute of Brain Science, School of Basic Medical Sciences, Hangzhou Normal University

BIO: Dr. Jiyun Peng is a professor at the Institute of Brain Science, School of Basic Medical Sciences at Hangzhou Normal University. He obtained his bachelor’s degree in life science in 2002, and PhD degree of neurobiology in 2009 at Fudan University. He then did his postdoc training with non-human primate work for 2 years at Duke University. After that, Dr. Jiyun Peng joined Dr. Long-Jun Wu lab at Rutgers University and turned to microglia research. In 2018, Dr. Jiyun Peng became independent and joined Nanchang University. In 2024, Dr. Peng moved to Hangzhou Normal University. Dr. Jiyn Peng's laboratory is mainly focusing on understanding how microglia regulate neuronal functions in physiological and pathological conditions, including neuropathic pain and itching. Dr. Jiyun Peng published series of first and last author papers, including in Nature communications, Cell Reports, Molecular Brain and Neuroscience Bulletin.
彭吉云，2009年博士毕业于复旦大学神经生物学研究所，毕业后先后在杜克大学，罗格斯大学和梅奥医学院完成博士后训练，于2018年入职南昌大学组建独立实验室,之后于2024年调任杭州师范大学基础医学院教授。主要研究方向：使用多种转基因小鼠、行为和电生理测试模型、荧光成像技术等解读神经胶质细胞（如小胶质细胞、少突胶质细胞）在慢性痛、痒传递、学习和记忆等病理生理过程中的参与机制。目前主持有国家自然科学基金地区项目，江西省自然科学基金重点项目，江西省“双千计划”项目等。主要研究成果以第一/通讯作者发表于Nature Communications (2016, 2022), Cell reports (2016, 2019), Glia (2023), Journal of Neuroscience (2017)和Neuroscience Bulletin (2021, 2023)等杂志。

○ 15:00-15:30 The role of bone marrow abnormalities in Radiation-induce Brain Injury
ZHOU, Li-Jun | 周利君 中山大学 中山医学院 Zhongshan School of Medicine, Sun Yat-sen University

BIO: Li-Jun Zhou (M.D., Ph.D.), is a professor at Pain Research Center of Sun Yat-sen University and Department of Physiology of Zhongshan school of Medicine, SYSU. She obtained her bachelor’s degree in Clinical Medicine from Xiangya Medical College of Central South University in 2001 and her Doctor's degree from Sun Yat-sen University in 2008. In 2012, she was awarded the seventh batch of universities in Guangdong Province "thousand hundred and ten projects" of higher education institutions in Guangdong Province. In 2013, she was awarded "Excellent Young Teacher of Higher Education in Guangdong Province". From 2014 to 2016, she worked as a postdoctoral fellow in the laboratory of Dr. Long-Jun Wu in the Department of Cell Biology and Neuroscience at Rutgers University. In 2016, she obtained "Guangdong Special Support Plan" tens of millions of young top-notch talents and in 2019, she won the " Rengao Ye and Youji Li " Outstanding Clinical Medicine Teacher Award of Sun Yat-sen University in 2018-2019. She has long been engaged in "pathophysiological studies of chronic itching and its comorbidities." Dr. Li-Jun Zhou has chaired four National Natural Science Foundation projects and more than 10 other research funds, including the Natural Science Foundation of Guangdong Province. She has published more than 20 first-author and last-author papers in journals such as Cell Rep, J Neurosci, Pain, Brain Behav Immuni, J Headache Pain and Theranostics. Her main research interestsare: 1) chronic pain and itch pain and their comorbidities; 2) Radiation-induce brain injury.
周利君，为中山大学疼痛研究中心、中山医学院生理教研室教授，博士研究生导师。20001年本科毕业于中南大学湘雅医学院临床专业；2008年获得中山大学医学博士学位。2012年获第七批广东省高等学校“千百十工程”校级培养对象；2013年被评为“广东省高等学校优秀青年教师”。2014~2016在美国罗格斯大学（Rutgers）细胞生物学与神经科学系Dr. Long-Jun Wu实验室做博士后。2016年获得“广东特支计划”百千万工程青年拔尖人才；2019年获得中山大学2018-2019年“叶任高-李幼姬”夫妇临床医学专业优秀教师奖。她长期致力于“慢性痛痒觉及其共病的病理生理研究”。 周利君博士主持和参与国家自然科学基金（4项）和广东省自然科学基金等20余项科研基金。在Cell Rep、J Neurosci、Pain、Brain Behav Immuni、J Headache Pain、Theranostics等期刊上发表了一系列第一作者和通讯作者论文。其主要研究方向：1）慢性痛痒疼痛及其共病；2）放射性脑病。

○ 15:30-16:00 Microglia regulate neuronal regeneration involved to pathogenesis of epilepsy
MO, Mingshu | 莫明树 广州医科大学附属第一医院神经内科 Guangzhou Medical University

BIO： Mingshu Mo got the PhD of Neurology from Sun Yat-sen University, and visited Rutgers University as Scholar member. He currently served as the deputy chief physician, associate researcher, and master's supervisor in the neurology of first affiliated hospital of Guangzhou medical university. He was selected as the global health talent reserve, Yangcheng scholars, Guangzhou high level health backbone talents and young reserve talents. He was member of American society for neuroscience, society of physiology, and international Parkinson's disease and movement disorders society. He was vice chairman of the youth committee of Neurology branch of Guangdong medical association, secretary of Guangdong interventional neurology professional committee, and other members of societies. He was granted two National Natural Science foundations, one Guangdong Provincial Natural Science foundation, one Yangcheng Scholar project, one Guangzhou Key Medical Specialty project, and other foundations. He have published over 40 papers, co-authored one monograph, and obtained one Chinese patent. He mainly focused on mechanism study and clinical treatment of neurodegenerative diseases and epilepsy, and was specializing in the diagnosis and treatment of central nervous system degenerative diseases such as cerebrovascular disease, Parkinson's disease, epilepsy, etc.
莫明树，中山大学神经病学博士，美国罗格斯大学访问学者。现任广州医科大学附属第一医院神经内科副主任医师，副研究员，硕士生导师。入选全球卫生人才后备库，羊城学者，广州市高层次卫生骨干人才、青年后备人才。美国神经科学协会（SfN）、生理学会（APS）成员，国际帕金森病与运动障碍学会（MDS）成员，广东省医学会神经病学分会青委会副主任委员，广东省介入神经病学专业委员会秘书及其他学会委员。承担国家自然基金项目2项、广东省自然科学基金面上项目1项、羊城学者项目1项、广州市重点医学专科1项及其他省市级项目。已发表SCI论文40余篇，参编专著1部，获国家发明专利1项。主要从事神经退行性疾病和癫痫的机制研究和临床医疗，擅长脑血管疾病、帕金森病等中枢神经变性病的诊治。

○ 16:00-16:30 全身麻醉与中枢神经免疫
YING, Yanlu | 应彦璐 广州市第一人民医院麻醉科 Guangzhou First People's Hospital

BIO：应彦璐，广州市第一人民医院手术麻醉中心副主任，医学博士，副主任医师，硕士研究生导师。2019-2021年在美国梅奥医学中心（Mayo Clinic) 神经科从事博士后研究员。主要研究方向为全身麻醉和中枢神经免疫。现任广东省医学会麻醉治疗学分会常务委员，广东省神经科学学会委员。主持国家自然科学基金2项，广东省自然基金面上项目1项， 以第一作者或通讯作者在Nature Neuroscience , Brain Behavior and Immunity等期刊 发表 SCI 论文十余篇，获评2023年度广东省医学会麻醉学分会“十大优秀青年” ，2024年度广东省医学会麻醉学青年菁英。

○ 16:30-17:00 小胶质细胞在神经变性过程中的动态行为
LIU, Yong | 刘勇 广州市第一人民医院神经免疫与健康实验室 Guangzhou First People's Hospital

BIO：广州市第一人民医院特聘研究员，神经免疫与健康实验室负责人，致力于带领团队运用双光子在体成像和神经电生理记录探索神经和胶质细胞的工作机理，以及其如何参与神经退行性疾病的发生和发展。2012年在中山大学中山医学院取得博士学位后，先后就职于美国国家衰老研究所(NIA/NIH)和梅奥医学中心(Mayo Clinic Rochester)。

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主办方：
广州市第一人民医院医学研究与创新转化中心
广州市第一人民医院神经免疫与健康实验室(LNHD.org)
广州市第一人民医院徕卡显微系统共建实验室

协办方：

地址：生物岛寰宇二路10号B栋9楼

交通指引：【会场定位】导航至“生物岛寰宇二路10号B栋”，从B栋一楼大门进入。

自驾指引：【停车场入口定位】导航至“广州国际生物岛园区-南区”前行5米右转进停车场负一楼，下坡后左转后右转，直行到底进入B区后停车，B栋电梯厅在前行方向左前方。